From: =?Windows-1252?Q?Enregistr=E9_par_Windows_Internet_Explorer=A07?= Subject: Document sans nom Date: Wed, 20 Aug 2008 00:30:20 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_00BE_01C9025B.EDB3E8C0" X-MimeOLE: Produced By Microsoft MimeOLE V6.0.6000.16545 This is a multi-part message in MIME format. ------=_NextPart_000_00BE_01C9025B.EDB3E8C0 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://spiral.univ-lyon1.fr/files_m/M1822/WEB/pages_web/MYCOLOGIE/onyxis_dermatophytique.htm Document sans nom
ONYXIS=20 DERMATOPHYTIQUE

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3Dpuce=20 D=E9finition=20
Infestation de l'ongle par un champignon = dermatophyte=20 anthropophile du genre T. rubrum (80 % des cas) ou T.=20 interdigitale (20 % des cas).

3Dpuce=20 = Epid=E9miologie
Repr=E9sente la=20 principale localisation des mycoses superficielles (30 =E0 40% de = l'ensemble=20 des dermatophyties).
Atteint surtout les ongles des orteils (80 = % des=20 cas). Tr=E8s fr=E9quent (pr=E9valence 8 =E0 14 %), surtout chez = les personnes=20 =E2g=E9es et rare chez l'enfant.
La transmission est = interhumaine par=20 contact direct ou indirect (sols, chaussures, linges = contamin=E9s). La=20 gu=E9rison ne s'observe qu'apr=E8s repousse d'un nouvel ongle (4 = =E0 6 mois pour=20 un ongle de la main et 9 =E0 12 mois pour un ongle du pied). Le = meilleur=20 crit=E8re de gu=E9rison est l'absence de rechute 6 mois apr=E8s la = fin du=20 traitement.

3Dpuce=20 Clinique
D=E9but par le bord = lat=E9ro-distal de=20 l'ongle, sans paronychie. Au d=E9but, l'ongle para=EEt d=E9coll=E9 = et la lame=20 superficielle devient opaque, blanch=E2tre, s'=E9paissit. L'ongle = se d=E9forme,=20 devient jaun=E2tre, friable et se d=E9truit progressivement. Dans = 2 =E0 5% des=20 cas : aspect de leuconychie (taches blanches = superficielles).=20
Diagnostic diff=E9rentiel : psoriasis, = ecz=E9ma,=20 lichen, ongle pathologique d'origine traumatique.

3Dpuce=20 Diagnostic=20
Pr=E9l=E8vement indispensable et syst=E9matique pour = examen direct et=20 mise en culture avant l'administration de tout traitement ou = apr=E8s 15=20 jours d'arr=EAt de celui-ci en cas d'antifongique topique, et 2 = mois d'arr=EAt=20 en cas de solution filmog=E8ne ou de traitement syst=E9mique.=20

3Dpuce=20 Prophylaxie
- Utiliser un = mat=E9riel de=20 p=E9dicure-manucure =E0 usage strictement personnel.
- Cf. = intertrigo=20 dermatophytique des petits plis.

Onyxis
Onyxis diffus
Leuconychie
3D"onyxis
3D"onyxis
3D"onyxis

(Dermatologie, = H=F4tel-Dieu,=20 Lyon)

(Parasitologie, = facult=E9 de=20 m=E9decine, Lyon) =


TRAITEMENT


Si un ou deux ongles sont atteints et si la = matrice est=20 conserv=E9e  :
3D"puce LOCERYL=AE (amorolfine) solution filmog=E8ne  : une ou = deux=20 applications par semaine jusqu'=E0 restitution totale de l'ongle. =

Si =E9chec du traitement local ou si = hyperk=E9ratose=20 sous-ungu=E9ale ou si plusieurs ongles atteints ou si la matrice = est=20 infect=E9e  :
LAMISIL=AE = (terbinafin)e=20 250mg : 1 cp /jour pendant 3 =E0 6 mois (main) et 6 =E0 12 = mois (pied).=20

Contre-indications=20 :
-=20 Hypersensibilit=E9
- Insuffisance = r=E9nale ou=20 h=E9patique s=E9v=E8re
- Grossesse et=20 allaitement

Effets=20 ind=E9sirables  :
- Perte du = go=FBt
-Troubles=20 digestifs
- H =E9patite
- R =E9actions cutan=E9es
- = Neutrop=E9nie
- Agranulocytose.

Surveillance =  :=20
fonctions h=E9patiques et NFS avant d=E9but du = traitement et apr=E8s 6=20 semaines.


Ordonnance pour un = adulte de 60kg=20
(Onychomycoses de plusieurs ongles des pieds =
avec=20 atteinte matricielle)

- LAMISIL=AE 250 mg :
=95 = Prendre un=20 comprim=E9 par jour au cours du repas pendant 3 mois.

Apr=E8s le d=E9but de la repousse de = l'ongle=20 l'associer =E0 :
- LOCERYL=AE solution=20 filmog=E8ne :
=95 Faire une application par = semaine sur les=20 ongles atteints pendant 6 mois.

Le traitement doit =EAtre poursuivi = jusqu' =E0 repousse=20 totale de l'ongle.

Consulter le m=E9decin au bout de 3 mois = de=20 traitement.

3Dpuce=20 Alternatives=20 th=E9rapeutiques

MYCOSTER=AE = (ciclopiroxolamine) 8 %=20 solution filmog=E8ne : 1 application par jour pendant 6 mois. =

3D"puce GRISEFULINE=AE (gris=E9ofulvine)=20 comprim=E9: cf. VIDAL.

3D"Fl=E8che
3D"Fl=E8che